Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats.
Md Abdul Hye KhanSung Hee HwangScott D BarnettAnna StavniichukWojciech K JankiewiczBruce D HammockJohn D ImigPublished in: British journal of pharmacology (2021)
Overall, the dual modulator PTUPB does not treat hyperglycaemia but can effectively alleviate hypertension, diabetic nephropathy, hyperlipidaemia and liver injury in type 2 diabetic rats. Our data further demonstrate that the renal actions of PTUPB are comparable with a current standard diabetic nephropathy treatment.