A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target.

Lucia CappabiancaStefano GuadagniRita MaccaroneMichela SebastianoAlessandro ChiomintoAntonietta Rosella FarinaAndrew Reay Mackay

Published in: Journal of experimental & clinical cancer research : CR (2019)

MCPyV positive MCCs but not MCPyV negative MCC, BCCs and SCCs exhibit predominant alternative TrkAIII splicing, with evidence of intracellular TrkAIII activation. This establishes a new potential MCC subset, unveils a novel potential MCPyV oncogenic mechanism and identifies TrkAIII as a novel potential therapeutic target in MCPyV positive MCC.

Keyphrases

human health
transcription factor
genome wide
risk assessment
dna methylation
climate change