Stereoselective Electro-2-deoxyglycosylation from Glycals.

Miao LiuKai-Meng LiuDe-Cai XiongHanyu ZhangTian LiBohan LiXianjin QinJinhe BaiXin-Shan Ye

Published in: Angewandte Chemie (International ed. in English) (2020)

We report a novel and highly stereoselective electro-2-deoxyglycosylation from glycals. This method features excellent stereoselectivity, scope, and functional-group tolerance. This process can also be applied to the modification of a wide range of natural products and drugs. Furthermore, a scalable synthesis of glycosylated podophyllotoxin and a one-pot trisaccharide synthesis through iterative electroglycosylations were achieved.

Keyphrases

high speed
image quality
computed tomography
mass spectrometry
dual energy