A Network Pharmacology Approach and Validation Experiments to Investigate the Mechanism of Wen-Dan Decoction in the Treatment of SINFH.

Baochuang QiMinzheng GuoXiangwen ShiMingjun LiYipeng WuYi WangQian LvXinyu FanChuan LiYongqing Xu

Published in: Combinatorial chemistry & high throughput screening (2024)

We provide new insights into the genes and related pathways involved in SINFH and report that PTGS2, RUNX2, and NCF1 are potential drug targets. Quercetin improved SINFH by promoting osteogenesis and inhibiting apoptosis.

Keyphrases

oxidative stress
endoplasmic reticulum stress
signaling pathway
cell death
transcription factor
gene expression
emergency department
drug induced
combination therapy