Neurometabolic Dysfunction in SPG11 Hereditary Spastic Paraplegia.
Martin RegensburgerLaura KrummManuel Alexander SchmidtAndreas SchmidImke Tabea SpatzDominique Cornelius MarterstockChristoph KoppZacharias KohlArnd DoerflerThomas KarraschBeate WinnerJuergen WinklerPublished in: Nutrients (2022)
Body composition, adipokine levels, and hypothalamic volume are altered in SPG11. Our data indicate a link between obesity and hypothalamic neurodegeneration in SPG11 and imply that specific metabolic interventions may prevent obesity despite severely impaired mobility in SPG11.