MicroRNA-150-5p is upregulated in the brain microvasculature during prenatal alcohol exposure and inhibits the angiogenic factor Vezf1.

Gabriela PeralesMarissa WestenskowRoxana GutierrezKevin K CaldwellAndrea M AllanAmy S Gardiner

Published in: Alcoholism, clinical and experimental research (2022)

miR-150-5p regulation of Vezf1 results in altered endothelial cell function during alcohol exposure. Further, miR-150-5p inhibition of Vezf1 may adversely alter the development of the cortical microvasculature during PAE and contribute to deficits seen in patients with FASD.

Keyphrases

pregnant women
traumatic brain injury
endothelial cells
white matter
multiple sclerosis
spectrum disorder