Human antibody reactivity against xenogeneic N-glycolylneuraminic acid and galactose-α-1,3-galactose antigen.

Sunghoon HurhBohae KangInho ChoiBumrae ChoEun Mi LeeHwajung KimYoung June KimYun Shin ChungJong Cheol JeongJong-Ik HwangJae Young KimByeong Chun LeeCharles D SurhJaeseok YangCurie Ahn

Published in: Xenotransplantation (2016)

We showed that IgG-mediated CDC was detected in Neu5Gc-overexpressed HEK293 cells incubated with human sera; however, this antibody reactivity to Neu5Gc was highly variable among individuals. Our results suggest that additional modifications to the CMAH gene should be considered for widespread use of pig organs for human transplants.

Keyphrases

endothelial cells
induced pluripotent stem cells
cell death
gene expression
genome wide
cell cycle arrest
endoplasmic reticulum stress