Detailed methylation map of LINE-1 5'-promoter region reveals hypomethylated CpG hotspots associated with tumor tissue specificity.

Ingo G H Schmidt-WolfMuhammad A JamilNicole NuesgenAlbertas DauksaAntanas GulbinasWolfgang A SchulzJohannes OldenburgOsman El-Maarri

Published in: Molecular genetics & genomic medicine (2019)

This study provides an accurate guide that will help to design further assays that could avoid artifacts and explain the variability of obtained LINE-1 methylation values between different studies.

Keyphrases

dna methylation
genome wide
gene expression
high resolution
high throughput
computed tomography
magnetic resonance
image quality
mass spectrometry