MR Elastography Analysis of Glioma Stiffness and IDH1-Mutation Status.
K M PepinKiaran P McGeeArvin AraniD S LakeK J GlaserArmando ManducaIan F ParneyRichard L EhmanJohn HustonPublished in: AJNR. American journal of neuroradiology (2017)
MR elastography demonstrated that not only were gliomas softer than normal brain but the degree of softening was directly correlated with tumor grade and IDH1-mutation status. Noninvasive determination of tumor grade and IDH1 mutation may result in improved stratification of patients for different treatment options and the evaluation of novel therapeutics. This work reports on the emerging field of "mechanogenomics": the identification of genetic features such as IDH1 mutation using intrinsic biomechanical information.
Keyphrases
- low grade
- wild type
- high grade
- end stage renal disease
- ejection fraction
- newly diagnosed
- magnetic resonance
- contrast enhanced
- healthcare
- emergency department
- computed tomography
- genome wide
- gene expression
- multiple sclerosis
- patient reported outcomes
- copy number
- mass spectrometry
- high resolution
- subarachnoid hemorrhage
- cerebral ischemia
- brain injury
- finite element