Potential Role of Inflammation-Promoting Biliary Microbiome in Primary Sclerosing Cholangitis and Cholangiocarcinoma.
Katsuyuki MiyabeVinay ChandrasekharaNicha WongjarupongJun ChenLu YangStephen JohnsonNicholas ChiaMarina Walther-AntonioJanet Z YaoSean C HarringtonCynthia K NordykeJohn E EatonAndrea A GossardSharad OliHamdi A AliSravanthi LavuNasra H GiamaFatima A HassanHawa M AliFelicity T EndersSumera I IlyasGregory J GoresMark D TopazianPurna C KashyapLewis Rowland RobertsPublished in: Cancers (2022)
We identified a unique microbial signature in the bile of patients with increased duration of PSC or with CCA, suggesting a role for microbiota-driven inflammation in the pathogenesis and or progression to perihilar CCA. Further studies are needed to test this hypothesis.
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