AIE + ESIPT activity-based NIR Cu2+ sensor with dye participated binding strategy.

Jie JiangHaifeng SunYanlei HuGang Lu Jiwei Cui Jingcheng Hao

Published in: Chemical communications (Cambridge, England) (2021)

A novel activity-based Cu2+ fluorescent probe featuring multidentate binding sites was synthesized. It functions through chelation with Cu2+, which in turn specifically triggers hydrolysis of the probe to release a near-infrared emission with AIE + ESIPT properties. The probe was found to be capable of ratiometric imaging of Cu2+ in living HeLa cells.

Keyphrases

fluorescent probe
living cells
aqueous solution
cell cycle arrest
induced apoptosis
metal organic framework
high resolution
cell death
oxidative stress
transcription factor
cell proliferation
nitric oxide
binding protein
endoplasmic reticulum stress
dna binding
solid state