5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis.

Sha JinDan CojocariJulie J PurkalRelja PopovicNari N TalatyYu XiaoLarry R SolomonErwin R BoghaertJoel D LeversonDarren C Phillips

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These data provide a novel nonepigenetic mechanism of action for 5-Aza and its combinatorial activity with venetoclax through the ISR-mediated induction of PMAIP1.

Keyphrases

acute myeloid leukemia
induced apoptosis
chronic lymphocytic leukemia
cell cycle arrest
electronic health record
big data
endoplasmic reticulum stress
oxidative stress
signaling pathway
machine learning