N-Acetyltransferase-2 (NAT2) phenotype is influenced by genotype-environment interaction in Ethiopians.

Eleni AklilluJuan Antonio CarrilloEyasu MakonnenLeif BertilssonNatasa Djordjevic

Published in: European journal of clinical pharmacology (2018)

We report a high prevalence of NAT 2 slow acetylators in Ethiopians and a conditional NAT2 genotype-phenotype discordance implicating a partial phenotype conversion and metabolic adaptation. Gene-environment interactions regulate NAT2 phenotype.

Keyphrases

gene expression
transcription factor