PKCθ Regulates Pituitary Adenoma Bone Invasion by Activating Osteoclast in NF-κB/IL-1β-Dependent Manner.

Quanji WangZhuowei LeiZihan WangQian JiangZhuo ZhangXiaojin LiuBiao XingSihan LiXiang GuoYanchao LiuXingbo LiKai ShuHuaqiu ZhangYimin HuangTing Lei

Published in: Cancers (2023)

By activating the PKCθ/NF-κB/IL-1β pathway, pituitary tumors are able to induce monocyte-osteoclast differentiation in a paracrine manner and promote bone invasion, which can be alleviated by celastrol.

Keyphrases

signaling pathway
bone loss
cell migration
pi k akt
bone mineral density
lps induced
nuclear factor
soft tissue
growth hormone
oxidative stress
bone regeneration
endothelial cells
protein kinase
inflammatory response
body composition
toll like receptor