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Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2.

Giulia PellizzariOlivier MartinezSilvia CrescioliRobert PageAshley Di MeoSilvia MeleGiulia ChiaruttiniJan HoinkaIhor BatruchIoannis PrassasMelanie GranditsJacobo López-AbenteEva Bugallo-BlancoMalcolm WardHeather J BaxElise FrenchAnthony CheungSara LombardiAlessandro Massimo GianniKatie E LacyEleftherios P DiamandisDebra H JosephsJames F SpicerSophie PapaSophia N Karagiannis
Published in: Journal for immunotherapy of cancer (2022)
These findings identify efficacious and potentially safe tumor-targeting of SLC3A2 with novel immune-activating antibody and genetically modified cell therapies.
Keyphrases
  • induced apoptosis
  • signaling pathway
  • cell cycle arrest
  • single cell
  • cell therapy
  • cancer therapy
  • drug delivery
  • oxidative stress
  • young adults
  • mesenchymal stem cells
  • cell proliferation