Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2.

Giulia Pellizzari Olivier Martinez Silvia Crescioli Robert PageAshley Di MeoSilvia Mele Giulia Chiaruttini Jan HoinkaIhor BatruchIoannis Prassas Melanie Grandits Jacobo López-Abente Eva Bugallo-Blanco Malcolm Ward Heather J BaxElise FrenchAnthony CheungSara Lombardi Alessandro Massimo Gianni Katie E Lacy Eleftherios P Diamandis Debra H Josephs James F Spicer Sophie Papa Sophia N Karagiannis

Published in: Journal for immunotherapy of cancer (2022)

These findings identify efficacious and potentially safe tumor-targeting of SLC3A2 with novel immune-activating antibody and genetically modified cell therapies.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest

single cell
cell therapy
cancer therapy

drug delivery
oxidative stress
young adults

mesenchymal stem cells
cell proliferation