Primary exposure to SARS-CoV-2 via infection or vaccination determines mucosal antibody-dependent ACE2 binding inhibition.
Janeri FröbergVera J C H KoomenChrista E van der Gaast-de JonghRia PhilipsenCorine H GeurtsvanKesselRory D de VriesMarije C BaasRenate G van der MolenMarien I De JongeLuuk B HilbrandsMartijn A HuynenDimitri A Diavatopoulosnull nullPublished in: The Journal of infectious diseases (2023)
Our study provides new insights into the relationship between antibody isotypes and neutralization by using a sensitive and high-throughput ACE2 binding inhibition assay. Key differences are highlighted between vaccination and infection at the mucosal level, showing that despite differences in the quantity of the response, post-infection and post-vaccination ACE2 binding inhibition capacity did not differ.