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Primary exposure to SARS-CoV-2 via infection or vaccination determines mucosal antibody-dependent ACE2 binding inhibition.

Janeri FröbergVera J C H KoomenChrista E van der Gaast-de JonghRia PhilipsenCorine H GeurtsvanKesselRory D de VriesMarije C BaasRenate G van der MolenMarien I De JongeLuuk B HilbrandsMartijn A HuynenDimitri A Diavatopoulosnull null
Published in: The Journal of infectious diseases (2023)
Our study provides new insights into the relationship between antibody isotypes and neutralization by using a sensitive and high-throughput ACE2 binding inhibition assay. Key differences are highlighted between vaccination and infection at the mucosal level, showing that despite differences in the quantity of the response, post-infection and post-vaccination ACE2 binding inhibition capacity did not differ.
Keyphrases
  • high throughput
  • sars cov
  • angiotensin converting enzyme
  • angiotensin ii
  • binding protein
  • single cell
  • respiratory syndrome coronavirus