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Clinical outcomes for pediatric patients receiving radiotherapy for solid tumor central nervous system metastases.

Thomas P HowardPatrick J BoyleKaren J MarcusDaphne A Haas-KoganKevin X Liu
Published in: Pediatric blood & cancer (2021)
Central nervous system (CNS) metastases are rare, but devastating complications of pediatric solid tumors. Radiotherapy alone or postresection serves as an important treatment; however, data on the use of whole-brain radiotherapy (WBRT) versus focal radiotherapy, including stereotactic radiosurgery or stereotactic radiotherapy, for these indications are limited. We report a single institution experience of 26 pediatric patients treated with radiotherapy for solid tumor CNS metastases without leptomeningeal disease. Focal radiotherapy (n = 10) was well tolerated and survival outcomes did not differ between patients treated with WBRT (n = 16) versus focal radiation, suggesting that focal radiotherapy may be considered for patients with limited CNS metastases.
Keyphrases
  • early stage
  • locally advanced
  • radiation induced
  • radiation therapy
  • rectal cancer
  • blood brain barrier
  • risk factors
  • multiple sclerosis
  • white matter
  • electronic health record