Influence of type-4 dipeptidyl peptidase inhibition on endothelium-dependent relaxation of aortae from a db/db mouse model of type 2 diabetes: a comparison with the effect of glimepiride.
Owen L WoodmanJacinta M OrtegaJoanne L HartThomas KleinSimon PotocnikPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2019)
Linagliptin is superior to glimepiride in regard to the preservation of endothelium-dependent relaxation in the presence of hyperglycemia and the improvement in endothelial function in response to linagliptin treatment is associated with greater antioxidant activity compared to glimepiride.