PPARγ activation by pioglitazone enhances the anti-proliferative effects of doxorubicin on pro-monocytic THP-1 leukemia cells via inducing apoptosis and G2/M cell cycle arrest.

Hassan Ghasemi Ali Jamshidi Mohammad Amin Ghatee Komeil Mazhab-Jafari Milad Mohammadoo-Khorasani Mina Rahmati Saeed Mohammadi

Published in: Journal of receptor and signal transduction research (2021)

We demonstrated that the antiproliferative, cell cycle regulation and apoptosis-inducing capacity of DOX was enhanced by PGZ in THP-1 leukemia cells in a dose-dependent manner. Therefore, the combination of DOX + PGZ could be used as a novel combination to target AML.

Keyphrases

cell cycle arrest
cell death
pi k akt
cell cycle
acute myeloid leukemia
cell proliferation
signaling pathway
bone marrow
drug delivery
type diabetes
insulin resistance
metabolic syndrome
adipose tissue
skeletal muscle
cancer therapy