Mutual amplification of GLI2/Hedgehog and cJUN/AP1 signaling in fibroblasts in Systemic Sclerosis (SSc) - potential implications for combined therapies.
Christina BergmannSara Chenguiti FakhouriTrinh-Minh ThuongTim FillaAleix Rius RigauArif B EkiciBenita MerlevedeLudwig HallenbergerHonglin ZhuClara DeesAlexandru Emil MateiJanina AuthAndrea-Hermina GyörfiXiang ZhouSimon RauberAline BozecNicholas DickelChunguang LiangMeik KunzLarissa Valor-MéndezJörg H W DistlerPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2024)
The transcription factors cJUN and GLI2 reinforce each other's activity to promote fibroblast activation in SSc. Interruption of this crosstalk by combined inhibition of both pathways exerts additive anti-fibrotic effects at well tolerated doses.