Toxicity and Anti-Inflammatory Effects of Agave sisalana Extract Derived from Agroindustrial Residue.
Luisa Taynara Silvério da CostaJulia Amanda Rodrigues FracassoLucas Pires GuarnierGustavo Reis de BritoDaniel Baldini FumisRenata Aparecida de Camargo BittencourtAimée Maria GuiottiDebora de Barros BarbosaIsabel Cristina Cherici CamargoEdislane Barreiros de SouzaPedro de Oliva NetoLucinéia Dos SantosPublished in: Plants (Basel, Switzerland) (2023)
It is suggested that the anti-edematogenic effect of the acid hydrolysis extract from sisal juice is due to the high concentration of steroidal sapogenins. Therefore, this extract can be considered a potential new anti-inflammatory or even an important sapogenin source for the development of steroidal glucocorticoids. However, further studies are needed to elucidate the chemical composition of sisal juice. Regarding toxicology studies, EAH did not show cytotoxic and clastogenic potentials, but it presented a powerful reproductive toxic effect in rats.