Functional estrogen receptor signaling pathway activity in high-grade serous ovarian carcinoma as compared to estrogen receptor protein expression by immunohistochemistry.
Phyllis van der PloegLaura A M van LieshoutAnja van de StolpeSteven L BoschMarjolein H F M Lentjes-BeerRuud L M BekkersJurgen M J PiekPublished in: Cellular oncology (Dordrecht) (2021)
Positive immunohistochemical ER staining is not always indicative of an active ER signaling pathway and is, therefore, a poor predictor of anti-estrogen response. Further research is needed to prove the predictive value of ER signaling pathway activity regarding anti-estrogen sensitivity in HGSC patients.