Cooperative regulation of adherens junction expansion through epidermal growth factor receptor activation.
Chaoyu FuAditya AroraWilfried EnglMichael SheetzVirgile ViasnoffPublished in: Journal of cell science (2022)
The mechanisms controlling the dynamics of expansion of adherens junctions are significantly less understood than those controlling their static properties. Here, we report that for suspended cell aggregates, the time to form a new junction between two cells speeds up with the number of junctions that the cells are already engaged in. Upon junction formation, the activation of epidermal growth factor receptor (EGFR) distally affects the actin turnover dynamics of the free cortex of the cells. The 'primed' actin cortex results in a faster expansion of the subsequent new junctions. In such aggregates, we show that this mechanism results in a cooperative acceleration of the junction expansion dynamics (kinetype) but does not alter the cell contractility, and hence the final junction size (phenotype). This article has an associated First Person interview with the first author of the paper.
Keyphrases
- epidermal growth factor receptor
- induced apoptosis
- tyrosine kinase
- advanced non small cell lung cancer
- cell cycle arrest
- single molecule
- small cell lung cancer
- single cell
- endoplasmic reticulum stress
- functional connectivity
- oxidative stress
- cell therapy
- cell death
- cell proliferation
- cell migration
- body composition