Non-Coding RNAs Regulate Spinal Cord Injury-Related Neuropathic Pain via Neuroinflammation.
Jing ZhuFei HuangYonglin HuWei QiaoYingchao GuanZhi-Jun ZhangSu LiuYing LiuPublished in: Journal of inflammation research (2023)
Secondary chronic neuropathic pain (NP) in addition to sensory, motor, or autonomic dysfunction can significantly reduce quality of life after spinal cord injury (SCI). The mechanisms of SCI-related NP have been studied in clinical trials and with the use of experimental models. However, in developing new treatment strategies for SCI patients, NP poses new challenges. The inflammatory response following SCI promotes the development of NP. Previous studies suggest that reducing neuroinflammation following SCI can improve NP-related behaviors. Intensive studies of the roles of non-coding RNAs in SCI have discovered that ncRNAs bind target mRNA, act between activated glia, neuronal cells, or other immunocytes, regulate gene expression, inhibit inflammation, and influence the prognosis of NP.
Keyphrases
- spinal cord injury
- neuropathic pain
- spinal cord
- gene expression
- inflammatory response
- clinical trial
- lps induced
- lipopolysaccharide induced
- oxidative stress
- end stage renal disease
- traumatic brain injury
- ejection fraction
- dna methylation
- cognitive impairment
- induced apoptosis
- newly diagnosed
- heart rate variability
- prognostic factors
- toll like receptor
- cell death
- cell proliferation