The role of glia in epilepsy, intellectual disability, and other neurodevelopmental disorders in tuberous sclerosis complex.
Michael WongPublished in: Journal of neurodevelopmental disorders (2019)
Different types of glial cells have both cell autonomous effects and interactions with neurons and other cells that are involved in the pathophysiology of the neurological phenotype of TSC. Targeting glial-mediated mechanisms may represent a novel therapeutic approach for epilepsy and TAND in TSC patients.
Keyphrases
- intellectual disability
- induced apoptosis
- cell cycle arrest
- autism spectrum disorder
- end stage renal disease
- ejection fraction
- neuropathic pain
- endoplasmic reticulum stress
- newly diagnosed
- spinal cord
- peritoneal dialysis
- prognostic factors
- cell death
- single cell
- spinal cord injury
- oxidative stress
- cell therapy
- drug delivery
- cell proliferation
- blood brain barrier
- pi k akt