CircMET promotes tumor proliferation by enhancing CDKN2A mRNA decay and upregulating SMAD3.

Lei YangYi ChenNing LiuYanwen LuWenliang MaZhenhao YangWeidong GanDongmei Li

Published in: Molecular cancer (2022)

CircMET promotes the development of NONO-TFE3 tRCC, and the regulation to both CDKN2A and SMAD3 of circMET was revealed. CircMET has the potential to serve as a novel target for the molecular therapy of NONO-TFE3 tRCC as well as the other cancer with high-expressing circMET.

Keyphrases

epithelial mesenchymal transition
transforming growth factor
papillary thyroid
signaling pathway
squamous cell
single cell
stem cells
squamous cell carcinoma
binding protein
young adults
single molecule
bone marrow
smoking cessation