Further evaluation of differential expression of keratoconus candidate genes in human corneas.

Justyna A Karolak Barbara Ginter-Matuszewska Katarzyna TomelaMichal KabzaDorota M Nowak-Malczewska Malgorzata RydzaniczPiotr PolakowskiJacek P SzaflikMarzena Gajecka

Published in: PeerJ (2020)

A strong correlation between RT-qPCR and earlier RNA-Seq data confirms the possible involvement of genes from collagen synthesis and the TGF-β, Hippo, and Wnt signaling pathways in KTCN etiology. Our data also revealed altered expression of several genes, such as LOX, SPARC, and ZNF469, in which single nucleotide variants have been frequently identified in KTCN. These findings further highlight the heterogeneous nature of KTCN.

Keyphrases

rna seq
single cell
electronic health record
genome wide
endothelial cells
signaling pathway
big data
stem cells
cell proliferation
bioinformatics analysis
genome wide identification
copy number
data analysis
binding protein
artificial intelligence