Ongoing HIV-1 evolution and reservoir reseeding in two elite controllers with genetically diverse peripheral proviral quasispecies.
Suwellen Sardinha Dias de AzevedoFernanda Heloise CôrtesLarissa M VillelaBrenda HoaglandBeatriz GrinsztejnValdilea Gonçalvez VelosoMariza G MorgadoGonzalo BelloPublished in: Memorias do Instituto Oswaldo Cruz (2023)
These findings support that the high intra-host HIV-1 diversity of some EC resulted from long-term persistence of archival proviruses combined with the continuous reservoir's reseeding and low, but measurable, viral evolution despite undetectable viremia.