Synthesis of Functionalized Difluorocyclopropanes: Unique Building Blocks for Drug Discovery.
Roman M BychekVadym V LevterovIryna V SadkovaAndrey A TolmachevPavel K MykhailiukPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2018)
Difluorocyclopropane-containing building blocks for drug discovery were synthesized from the functionalized alkenes and TMSCF3 /NaI. Novel fluorinated acids, amines, amino acids, alcohols, ketones and sulfonyl chlorides were obtained.