The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis.
Ricardo Sant'AnnaBruno K RobbsJúlia Araújo de FreitasPatrícia Pires Dos SantosAnnekatrin KönigTiago Fleming OuteiroDebora FoguelPublished in: Molecular medicine (Cambridge, Mass.) (2023)
For the first time a direct role of NFAT in aSyn-O-induced toxicity and Syn1 gene regulation was demonstrated, enlarging our understanding of the pathways underpinnings synucleinopathies.