Pulmonary Edema in COVID19-A Neural Hypothesis.
Anoop U RKavita VermaPublished in: ACS chemical neuroscience (2020)
In COVID-19, lung manifestations present as a slowly evolving pneumonia with insidious early onset interstitial pulmonary edema that undergoes acute exacerbation in the late stages and microvascular thrombosis. Currently, these manifestations are considered to be only consequences of pulmonary SARS-CoV-2 virus infection. We are proposing a new hypothesis that neurogenic insult may also play a major role in the pathogenesis of these manifestations. SARS-CoV-2 mediated inflammation of the nucleus tractus solitarius (NTS) may play a role in the acute exacerbation of pulmonary edema and microvascular clotting in COVID-19 patients.
Keyphrases
- sars cov
- early onset
- pulmonary hypertension
- respiratory failure
- respiratory syndrome coronavirus
- chronic obstructive pulmonary disease
- liver failure
- coronavirus disease
- late onset
- oxidative stress
- drug induced
- pulmonary embolism
- spinal cord injury
- extracorporeal membrane oxygenation
- intensive care unit
- hepatitis b virus