Integrative studies implicate matrix metalloproteinase-12 as a culprit gene for large-artery atherosclerotic stroke.

H MahdessianLjubica MaticM LengquistK GertowB SennbladD BaldassarreF VegliaS E HumphriesR RauramaaU de FaireA J SmitP GiralS KurlE MannarinoE TremoliA HamstenP ErikssonU HedinA Mälarstignull null

Published in: Journal of internal medicine (2017)

Our study supports the notion that MMP12 is implicated in large-artery atherosclerotic stroke, functionally by enhancing elastin degradation and macrophage invasion in plaques.

Keyphrases

atrial fibrillation
cell migration
adipose tissue
copy number
cerebral ischemia
brain injury