Adverse events associated with currently used medical treatments for cystinuria and treatment goals: results from a series of 442 patients in France.
Caroline Prot-BertoyeSaïd LebbahMichel DaudonIsabelle TostivintJean-Philippe JaisAgnés Lillo-Le LouëtClément PontoizeauPierre CochatPierre BatailleFranck BridouxPierre BrignonChristian ChoquenetChristian CombePierre ConortStéphane DecramerBertrand DoréBertrand DussolMarie EssigMarie FrimatNicolas GaunezDominique JolySophie Le Toquin-BernardArnaud MéjeanPaul MeriaDenis MorinHung V N'GuyenMichel NormandMichel PietakPierre RoncoChristian SaussineMichel TsimaratosGérard FriedlanderOlivier TraxerBertrand KnebelmannMarie Courbebaissenull nullPublished in: BJU international (2019)
Adverse events were frequent with D-penicillamine and tiopronin. Alkaline hyperdiuresis was well tolerated and reduced cystine crystalluria. Urine specific gravity ≤1.005 and urine pH >7.5, while warning about calcium-phosphate crystallization, should be the goals of medical therapy.