Supernatants of irritable bowel syndrome mucosal biopsies impair human colonic smooth muscle contractility.

M P GuarinoG BarbaraA CiceniaA AltomareM R BarbaroS CoccaA SciroccoCesare CremonS EmerenzianiV StanghelliniM CicalaC Severi

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2016)

Supernatants from mucosal biopsies of IBS patients reduce colonic contractility. The observed impairment was concentration dependent, likely occurring through intracellular oxidative stress damage, involving different neuromotor mechanisms depending on the IBS subtype.

Keyphrases

smooth muscle
irritable bowel syndrome
oxidative stress
ulcerative colitis
end stage renal disease
endothelial cells
newly diagnosed
peritoneal dialysis
prognostic factors
dna damage
ultrasound guided
heat shock protein