Spironolactone Attenuates Methylglyoxal-induced Cellular Dysfunction in MC3T3-E1 Osteoblastic Cells.

So Young Park Kwang Sik Suh Woon-Won Jung Sang Ouk Chin

Published in: Journal of Korean medical science (2021)

Spironolactone could prevent MG-induced cytotoxicity in MC3T3-E1 osteoblastic cells by reduction of oxidative stress. The oxidative stress reduction was explained by spironolactone's inhibition of advanced glycation end-product formation, restoring mitochondrial dysfunction, and anti-inflammatory effect.

Keyphrases

oxidative stress
induced apoptosis
diabetic rats
cell cycle arrest
endoplasmic reticulum stress
high glucose
anti inflammatory
signaling pathway
dna damage
ischemia reperfusion injury
vascular smooth muscle cells
drug induced
cell death
endothelial cells
heat shock