Premature ovarian failure (POF, POI - premature ovarian insufficiency) is a serious situation for a woman with reproductive plans that more or less precludes having her own bio-logical child. In addition to the lack of functional oocytes in the ovaries, it is also a premature lack of sex hormones, which has an overall negative effect on health. The article guides us through care both in the clinic of the gynecologist and through treatment in the center of reproductive medicine. The dia-gnosis and treatment of POF illustrates some endocrinological principles and connections.