Clinical significance of circulating microRNAs as markers in detecting and predicting congenital heart defects in children.

Yong SongHilda HigginsJing GuoKatrina HarrisonEn Nee SchultzBelinda J HalesEric K MosesJack GoldblattNicholas PachterGuicheng Zhang

Published in: Journal of translational medicine (2018)

Circulating miRNAs are important markers not only for diagnosing CHD, but also for predicting CHD risk in offspring. The distinct miRNA signatures are likely to present in various subtypes of CHD, and the phenotypic heterogeneity of CHD should be considered to develop such miRNA-based assays.

Keyphrases

young adults
high throughput
high fat diet
single cell
type diabetes
genome wide
metabolic syndrome
insulin resistance