Ruthenium-Catalyzed meta-Carboxylation.
Helen L BarlowChristopher J TeskeyMichael F GreaneyPublished in: Organic letters (2017)
The meta-carboxylation of arenes containing pyridine and other azine-directing groups is reported. Using carbon tetrabromide as the C1 source, ruthenium(III) trichloride catalysis enables functionalization of the arene meta-C-H position, affording carboxy methyl ester products after in situ reaction with methanol.
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