Comment on Lai et al. Dipeptidyl Peptidase 4 Stimulation Induces Adipogenesis-Related Gene Expression of Adipose Stromal Cells. Int. J. Mol. Sci. 2023, 24 , 16101.
Oscar J CorderoMartin KotrulevIria Gomez-TouriñoPublished in: International journal of molecular sciences (2024)
Adiponectin is a circulating hormone secreted by adipose tissue that exerts, unlike other adipokines such as leptin, anti-inflammatory, anti-atherosclerotic and other protective effects on health. Adiponectin receptor agonists are being tested in clinical trials and are expected to show benefits in many diseases. In a recent article, LW Chen's group used monocyte chemoattractant protein-1 (MCP-1/CCL2) to improve plasma levels of adiponectin, suggesting the involvement of dipeptidyl peptidase 4 (DPP4/CD26) in the mechanism. Here, we discuss the significance of the role of DPP4, favoring the increase in DPP4-positive interstitial progenitor cells, a finding that fits with the greater stemness and persistence of other DPP4/CD26-positive cells.
Keyphrases
- insulin resistance
- adipose tissue
- gene expression
- metabolic syndrome
- clinical trial
- anti inflammatory
- induced apoptosis
- healthcare
- high fat diet
- stem cells
- public health
- dna methylation
- spinal cord injury
- epithelial mesenchymal transition
- dendritic cells
- cell cycle arrest
- skeletal muscle
- nk cells
- endothelial cells
- oxidative stress
- amino acid
- small molecule
- liver injury
- binding protein
- cancer stem cells