Molecular basis underlying changes of brain entropy and functional connectivity in major depressive disorders after electroconvulsive therapy.
Xiaohui YuKexuan ChenYingzi MaTongjian BaiShunli ZhuDefang CaiXing ZhangKai WangYuanghua TianJiaojian WangPublished in: CNS neuroscience & therapeutics (2024)
Compared to pretreatment, the BEN in the posterior cerebellar lobe (PCL) significantly decreased and FC between the PCL and the right temporal pole (TP) significantly increased in MDD patients after treatment. Moreover, we found that these changes of BEN and FC were closely associated with genes' expression profiles involved in MAPK signaling pathway, GABAergic synapse, and dopaminergic synapse and were significantly correlated with the receptor/transporter density of 5-HT, norepinephrine, glutamate, etc. CONCLUSION: These findings suggest that loops in the cerebellum and TP are crucial for ECT regulation of mood and cognition, which provides new evidence for the antidepressant effects of ECT and the potential molecular mechanism leading to cognitive impairment.
Keyphrases
- functional connectivity
- resting state
- signaling pathway
- major depressive disorder
- cognitive impairment
- bipolar disorder
- end stage renal disease
- pi k akt
- ejection fraction
- newly diagnosed
- oxidative stress
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- epithelial mesenchymal transition
- genome wide
- multiple sclerosis
- patient reported outcomes
- stress induced
- induced apoptosis
- binding protein
- human health
- patient reported