Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson's disease.

Julian L GoggiLifeng QiuMei Chih LiaoShivashankar KhanapurLingfan JiangRamasamy BoominathanSiddesh V HartimathPeter ChengFui Fong YongVanessa SohXiaozhou DengYoushan Melissa LinAnna HaslopPeng Wen TanXiaoxia ZengJolene W L LeeZhiwei ZhangPragalath SadasivamEng King TanSajinder K LuthraWilliam D ShingletonSteve K W OhLi ZengEdward G Robins

Published in: Stem cell research & therapy (2020)

This study provides further evidence for the value of in vivo functional imaging for the assessment of cell therapies and highlights the utility of DAT imaging for the determination of early post-transplant cell maturation and differentiation of hESC-mDAs.

Keyphrases

cell therapy
high resolution
single cell
uric acid
spinal cord
spinal cord injury
prefrontal cortex
bone marrow
photodynamic therapy
simultaneous determination