Enhanced B-cell differentiation driven by advanced cirrhosis resulting in hyperglobulinemia.

Hiroyoshi DoiEiichi HayashiJun AraiMasayuki TojoKenichi MorikawaJunichi EguchiTakayoshi ItoTatsuya KantoDavid E KaplanHitoshi Yoshida

Published in: Journal of gastroenterology and hepatology (2018)

Enhanced TLR9-induced differentiation into antibody secreting cell may explain peripheral reductions of circulating CD27+ memory B cells as well as increased serum Ig levels in cirrhosis.

Keyphrases

single cell
toll like receptor
high glucose
diabetic rats
immune response
cell therapy
working memory
drug induced
stem cells
oxidative stress
nk cells