Pseudomonas aeruginosa colonization in cystic fibrosis: Impact on neutrophil functions and cytokine secretion capacity.
Umit AslanhanErkan CakirLeyla Pur OzyigitUmut Can KucuksezerMetin Yusuf GelmezMine YukselGunnur DenizEsin Cetin AktasPublished in: Pediatric pulmonology (2021)
Our findings confirm inadequate neutrophil defense towards pathogens in CF. A significant difference in migration, phagocytosis, oxidative burst, percentage of IL-8 producing neutrophils, IL-1β, TNF-α, and IL-17 secretions were noted among CF patients according to their colonization status, which might induce a further destructive effect on airways, resulting in an unfavorable prognosis for children with CF who also have colonization.
Keyphrases
- gram negative
- cystic fibrosis
- pseudomonas aeruginosa
- multidrug resistant
- lung function
- end stage renal disease
- acinetobacter baumannii
- biofilm formation
- newly diagnosed
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- young adults
- rheumatoid arthritis
- prognostic factors
- high frequency
- chronic obstructive pulmonary disease
- patient reported outcomes
- innate immune