Expression of TLR4-PTGE2 signaling genes in atherosclerotic carotid plaques and peripheral blood.
S FerronatoA ScuroS FochiE OrlandiMacarena Gomez-LiraS OlivatoSara MazzuccoAlberto TurcoMaria Grazia RomanelliPublished in: Molecular biology reports (2018)
Toll-like receptor 4 (TLR4)/prostaglandine synthetase 2 (PTGS2) signaling plays a relevant role in atherosclerotic plaque vulnerability. The purpose of this study was to check the gene expression of 6 genes participating to TLR4/PTGS2 signaling (TLR4, PTGS2, ACSL4, PTGER3, PTGER4, and EPRAP) in carotid plaques and blood samples from the same individual and to evaluate these genes as biomarker of plaque progression. We investigated differential gene expression by qRT-PCR in 62 atherosclerotic patients' carotid plaques and corresponding blood sample. A very weak or no correlation was observed in the overall population or analyzing asymptomatic patients. These analyzed genes are most likely not suitable for inclusion in the clinical routine as biomarkers of plaque instability.
Keyphrases
- toll like receptor
- gene expression
- inflammatory response
- immune response
- end stage renal disease
- nuclear factor
- genome wide
- newly diagnosed
- ejection fraction
- peripheral blood
- dna methylation
- coronary artery disease
- chronic kidney disease
- prognostic factors
- climate change
- binding protein
- genome wide analysis
- high speed