Autoimmune Encephalitis Resembling Dementia Syndromes.

Anna E M BastiaansenRobin W van SteenhovenMarienke A A M de BruijnYvette S CrijnenAgnes van SonderenMarleen H van Coevorden-HameeteMarieke M NühnMarcel M VerbeekMarco W J SchreursPeter A E Sillevis SmittJuna M de VriesFrank Jan de JongMaarten J Titulaer

Published in: Neurology(R) neuroimmunology & neuroinflammation (2021)

Red flags for AIE in patients with suspected dementia are: (1) rapidly progressive cognitive decline, (2) subtle seizures, and (3) abnormalities in ancillary testing atypical for neurodegeneration. Physicians should be aware that inflammatory changes are not always present in AIE, and that biomarkers often requested when dementia was suspected (including 14-3-3) can show abnormal results. Diagnosis is essential as most patients profit from immunotherapy.

Keyphrases

mild cognitive impairment
cognitive decline
cognitive impairment
end stage renal disease
multiple sclerosis
ejection fraction
primary care
chronic kidney disease
living cells
fluorescent probe
oxidative stress
peritoneal dialysis
prognostic factors
pulmonary embolism
patient reported outcomes