Differences in somatic TP53 mutation type in breast tumors by race and receptor status.

Nijole C PollockJohnny R RamroopHeather HampelMelissa A TroesterKathleen ConwayJennifer J HuJo L FreudenheimOlufunmilayo I OlopadeDezheng HuoElad ZivSusan L NeuhausenPatrick StevensJoseph Paul McElroyAmanda Ewart Toland

Published in: Breast cancer research and treatment (2022)

Somatic TP53 mutation types did not differ by ancestry overall, but GOF mutations were more common in NHW women than AA women. ER-negative and TNBC tumors are less likely to have DNE+ TP53 mutations which could reflect biological processes. Larger cohorts and functional studies are needed to further elucidate these findings.

Keyphrases

polycystic ovary syndrome
pregnancy outcomes
copy number
cervical cancer screening
breast cancer risk
estrogen receptor
adipose tissue
case control
genome wide
endoplasmic reticulum
binding protein