Changes in Digital Speech Measures in Asymptomatic Carriers of Pathogenic Variants Associated With Frontotemporal Degeneration.

Naomi Nevler Sunghye Cho Katheryn Alexandra Quilico Cousins Sharon Ash Christopher A Olm Sanjana Shellikeri Galit Agmon Carmen Gonzalez-Recober Eleni-Rosalina Andrinopoulou Megan S Barker Masood Manoochehri Corey T McMillan David John Irwin Lauren Massimo Laynie DratchGayathri CheranEdward D HueyStephanie A Cosentino Vivanna M Van Deerlin Mark Y LibermanMurray Grossman

Published in: Neurology (2023)

Using automatic processing pipelines, we identified early changes in the natural speech of FTD pathogenic variant carriers in the presymptomatic stage. These findings highlight the potential utility of natural speech as a digital clinical outcome assessment tool in FTD, where objective and quantifiable measures for abnormal behavior and language are lacking.

Keyphrases

hearing loss
autism spectrum disorder
machine learning
deep learning
copy number
gene expression
risk assessment
genome wide