Testicular germ cell tumour arising 15 years after radiotherapy with 18 Gy for germ cell neoplasia in situ.

Klaus Peter DieckmannSilke TribiusMathias AngererAndrea SalzbrunnKathrein von KopylowMartin MollenhauerChristian Wülfing

Published in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (2022)

Cumulative experience suggests that radiotherapy with 18-20 Gy to the testis may fail with an estimated frequency of around 1%. Reasons for failure are elusive. A primary radioresistant subfraction of GCNis is hypothesized as well as technical failures regarding application of the radiotherapeutic dose volume in small and mobile testes. Caregivers of patients with TSS and contralateral GCNis should be aware of local relapses occurring after intervals of > 10 years.

Keyphrases

germ cell
early stage
locally advanced
radiation induced
radiation therapy
palliative care
high grade
rectal cancer
rare case