Mesoporous polydopamine-coated hydroxyapatite nano-composites for ROS-triggered nitric oxide-enhanced photothermal therapy of osteosarcoma.
Yong-Chao WangHong-Lian DaiZe-Hao LiZhi-Yuan MengYao XiaoZheng ZhaoPublished in: Journal of materials chemistry. B (2021)
In this paper, MPDA@hydroxyapatite nanocomposites (MPHA NCs) were prepared and applied to develop a novel reactive oxygen species (ROS)-triggered nitric oxide (NO)-enhanced photothermal therapy nanocomposite system composed of indocyanine green (ICG)/L-arginine-MPDA@HAp (AI-MPHA NCs) for displaying both NO gas therapy and photothermal osteosarcoma treatment. The nanosystem exhibited a mesoporous and core-shell structure and high ICG loading efficiency (about 90%). Under near infrared (NIR) irradiation, the AI-MPHA NCs could not only produce heat but also generate reactive oxygen species (ROS), inducing the catalysis of L-Arg to obtain NO. Under NIR irradiation, the AI-MPHA NCs achieved osteosarcoma ablation by a synergistic combination of photothermal therapy and NO-gas therapy. Additionally, the cell viability of MG-63 cells decreased to 23.6% (co-incubated with AI-MPHA NCs) under irradiation with a power density at 1.0 W cm-2 for 10 min. The study proposed a novel nano-platform for NO-enhanced photothermal therapy of osteosarcoma.
Keyphrases
- reactive oxygen species
- nitric oxide
- artificial intelligence
- fluorescence imaging
- photodynamic therapy
- reduced graphene oxide
- nitric oxide synthase
- drug release
- hydrogen peroxide
- induced apoptosis
- cell death
- visible light
- dna damage
- cancer therapy
- room temperature
- machine learning
- drug delivery
- radiation induced
- cell cycle arrest
- high throughput
- carbon nanotubes
- radiation therapy
- mesenchymal stem cells
- signaling pathway
- heat stress
- single cell
- replacement therapy
- endoplasmic reticulum stress
- cell proliferation
- combination therapy
- atrial fibrillation