The effect of duloxetine on mechanistic pain profiles, cognitive factors and clinical pain in patients with painful knee osteoarthritis-A randomized, double-blind, placebo-controlled, crossover study.
Kristian Kjaer-Staal PedersenAsbjørn Mohr DrewesAnne Estrup OlesenNadia AmmitzbøllDavide BertoliChristina BrockLars Arendt-NielsenPublished in: European journal of pain (London, England) (2022)
Duloxetine is proposed as a treatment for chronic pain. Pre-clinical trials suggest that duloxetine provides analgesia through modulation of descending pain inhibitory pathways or through improvements in cognitive factors. The current study demonstrates that pretreatment mechanistic pain profiling, cognitive factors and clinical pain can predict the analgesic effect of duloxetine and that only a subset of patients might benefit from duloxetine treatment.
Keyphrases
- chronic pain
- pain management
- neuropathic pain
- knee osteoarthritis
- clinical trial
- double blind
- end stage renal disease
- ejection fraction
- chronic kidney disease
- squamous cell carcinoma
- prognostic factors
- newly diagnosed
- spinal cord
- spinal cord injury
- peritoneal dialysis
- postoperative pain
- single cell
- radiation therapy
- study protocol